Review side effects, dosage, drug interactions, warnings and. The fixeddose efavirenz emtricitabinetenofovir efvftctdf atripla is a firstline agent for the treatment. Brief efavirenz sustiva, efv nonnucleoside reverse. Efavirenz is a cyp substrate, leading to concern for decreased efavirenz. Our sustiva efavirenz side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Taking sustiva with alcohol, medicine for mental health problems, or certain street drugs can worsen side effects.
Sustiva, efavirenz dosing, indications, interactions. Call your doctor for medical advice about side effects. Highlights of prescribing information these highlights do not include all the information needed to use atripla safely and effectively. Adverse neuropsychiatric events and recreational use of efavirenz.
Article information, pdf download for effect of valerian in preventing. Other serious side effects include depression, thoughts of suicide, liver problems, and seizures. Efavirenz comes as a capsule and as a tablet to take by mouth. The majority of efavirenz induced cns effects appear early, even after a single dose, and mitigate within 1 month. More severe side effects are hallucinations, sleeplessness and depression.
Efavirenz is used as part of combination therapy for people with hiv. Sustiva efavirenz is one of the most widely used and effective components of an hiv medication regimen. While one study showed that the neuropsychiatric side effects of efavirenz go away in 10 to 12 weeks, the study stopped at 24 weeks, hardy said. Common side effects of efavirenzemtricitabinetenofovir are tiredness, dizziness, gastrointestinal distress, and skin discoloration. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat. Efavirenz is 1,4dihydro2h3,1benzoxazin2one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups s configuration and at the 6 position by. Because atripla is a fixeddose combination product, the dose of efavirenz. Sustiva efavirenz side effects, images, uses, dosage. Some side effects of efavirenz emtricitabine tenofovir may occur that usually do not need medical attention.
However, about one half of persons who take efavirenz develop neuropsychiatric side effects, including trouble sleeping, nightmares, dizziness. Check with your health care professional if any of the following side effects. Currently, efavirenz efv is widely prescribed as part of antiretroviral therapy art. Adverse events related to the study drug were more frequent with 600 mg efavirenz than with 400 mg.
These side effects may go away during treatment as your body adjusts to the medicine. Several neuropsychiatric adverse effects of efavirenz are. Efavirenz and neuropsychiatric effects southern african hiv. It is a nonnucleoside reverse transcriptase inhibitor nnrti and works by blocking the function of reverse transcriptase. These findings would lead us to conclude that many patients are being treated with efavirenz with no ocular side effects and that perhaps the. Webmd provides common contraindications for efavirenz oral. Symfi is a threedrug fixeddose combination product containing 600 mg of efavirenz.
Neuropsychological side effects of efavirenz annals of. These are not all the possible side effects of efavirenz. You can report side effects to fda at 1800fda1088 18003321088 or online. Efavirenz is recommended as a preferred firstline drug for women of childbearing potential living with human immunodeficiency virus. Pdf psouth africa has the highest proportion of hivpositive people in the world. Efavirenz is known for its central nervous system side effects. This is not a complete list of side effects and others may occur. Atripla is a prescription medicine that contains efavirenz. Also, voriconazole significantly increases efavirenz plasma concentrations, which may increase the risk of efavirenz associated side effects.
These side effects are more pronounced in the first 12 weeks of treatment. Efavirenz is associated with causing neuropsychiatric sideeffects npses, with almost 50% of patients. Our findings suggest that a reduced dose of 400 mg efavirenz is noninferior to the standard dose of 600 mg, when combined with tenofovir and emtricitabine during 48 weeks in artnaive adults with hiv1 infection. Neuropsychiatric side effects of efavirenz therapy. Find out what health conditions may be a health risk when taken with efavirenz oral. Pdf neuropsychiatric side effects of efavirenz therapy.
Efavirenz has the highest antiproliferative effect. Neuropsychological side effects of efavirenz article, author, and disclosure information. Patient information what is the most important information. Comparison of side effects with 2 doses of the hiv drug efavirenz.
Drugassociated hepatotoxicity has been well defined in the literature. As efavirenz and rilpivirine had the highest cytotoxic potential and. Concerns regarding the use of efavirenz in patients with a history of mental illness may predispose clinicians to not offer this agent to psychiatrically ill populations. Drug information on sustiva efavirenz includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Efavirenz is an effective antiretroviral agent, but central nervous system side effects occur commonly, and population racial differences in pharmacokinetics and response have been reported. Taking the pill in the evening, just before bedtime, improves the tolerability of central nervous system side effects. Effect of valerian in preventing neuropsychiatric adverse effects of.
Pdf pharmacogenetics of efavirenz and central nervous. Taking efavirenz at bedtime may make certain side effects. Occasionally patients report disabling side effects which persist beyond this induction period, necessitating switching from efavirenz. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. The effects of coadministration of efavirenz on the auc and c. Efavirenz does not reduce the risk of transmission of hiv to others through sexual contact or blood contamination. It is usually taken once a day with plenty of water on an empty stomach at least 1 hour before or 2 hours after a meal. Dailymed symfi efavirenz, lamivudine and tenofovir. Efavirenz is a commonly prescribed antiretroviral drug that is largely well tolerated. However, it is not a firstline choice because it can have a lot of side effects. Doctors find effective hiv drug course free of efavirenz. Recommended dosage for efavirenzemtricitabinetenofovir is one tablet at or before bedtime.
Neuropsychiatric side effects dizziness, headache, insomnia, impaired concentration, abnormal dreams are the most common adverse reactions seen with. Except as otherwise noted, this work is licensed under a creative. Some of the most bothersome are neurologic or psychological problems. Some side effects of efavirenz may occur that usually do not need medical attention. Not recommended with atripla, which contains efavirenz, emtricitabine, and tenofovir disoproxil fumarate, unless needed for dose adjustment when coadministered with rifampin. Identification of the substancemixture and of the companyundertaking product name. Taking this drug with food results in an increase of efavirenz concentration in the blood and thus lead to the side effects. Efavirenz based art is a firstline treatment option for hiv in both us and international guidelines. Find information about common, infrequent and rare side effects of efavirenz oral. Taking sustiva with food increases the amount of medicine in your body, which may increase the frequency of side effects. Taking sustiva at bedtime may make some side effects less bothersome. Side effects of sustiva efavirenz, warnings, uses rxlist. Efavirenz sustiva page 1 of 7 factfact tsheet efavirenz sustiva summary efavirenz is a type of antihiv drug from a class of drugs commonly called nonnukes.
Central nervous system adverse effects with efavirenz. Efavirenz is an effective antiretroviral agent, but central nervous system side effects occur commonly, and population racial differences in pharmacokinetics and response have been. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or. For more information about side effects see the section, what are the possible side effects of atripla. Acute liver toxicity due to efavirenzemtricitabinetenofovir. Advise patient that the longterm effects of efavirenz are unknownatthistime. Caution patient to use a condom and to avoid sharing needles or donating blood to prevent spreading the aids virus to others. Efavirenz side effects, dosage, interactions drugs. To learn more about possible side effects of efavirenz, read the drug label or package insert or talk to your health care provider or pharmacist. Neuropsychiatric side effects and illicit use of efavirenz. Efavirenz pharmacokinetics and pharmacodynamics in hiv. Find patient medical information for efavirenz oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Efavirenz is associated with neuropsychiatric effects including dizziness, abnormal dreams, insomnia, hallucination and euphoria. Your healthcare provider will test you for hbv before starting.
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